Abstract

Vandana Malviya*, Dr. Mehta Parulben D. and Priyanka Namdeo

ABSTRACT

The prime objective of this work was to formulate selenium nanoparticles, surface decorate them with gallic acid, load venlafaxine in the nanoparticles and evaluate the colon targeting ability of the surface functionalized selenium nanoparticles. Venlafaxine has been widely prescribed drug for management of depression. The surface decoration of the SeN with gallic acid was achieved in alkaline pH using 0.1N NaOH to adjust the pH and drug loading was achieved by continual stirring for long duration. The synthesized SeN and SeN-G were characterized for shape, size, UV absorption, FTIR, entrapment efficiency and in vitro release of venlafaxine in presence and absence of rat caecal content. The formation of Se NP is indicated by the UV spectrum showing absorbance at 226.0 nm. The FTIR spectrum revealed the stretching and bending vibrations of O-H, C-H, C-C, N-O, C-N and other groups due to the presence of gallic acid. The particle size of the SeN and SeN-G was found to be 46 and 67 nm respectively and the SEM images displayed smooth particles with spherical structure. The percent entrapment was found to be 63.4% in SeN-G and 63.1% in SeN. In absence of the caecal medium, the release of drug from SeN 61.23% in 24 h whereas SeN released more than 75%. On the other hand, in the presence of colonic media (caecal medium) the release with gallic acid decorated particles was increased to 94.82% in 24 h.