NETWORK PHARMACOLOGY-BASED EXPLORATION OF ACTIVE COMPONENTS AND TARGETS OF ACTION OF LICORICE-DRIED GINGER SOUP AGAINST NOVEL CORONAVIRUSES
Chen Wei, Hongge Zhang, Huihui Fang, Yangjie Zuo, Yubing Shi and Jing Dong*
ABSTRACT
Objective: In clinical practice, Licorice ginger soup has been utilized to treat new coronavirus pneumonia, and this study looked into the potential targets and mechanisms of action of licorice ginger soup from the perspective of network pharmacology. Methods: To begin, the chemical makeup and target of action of licorice dried ginger were obtained using the TCMSP database. Next, COVID-19 targets were retrieved in the Genecards database, common targets for drugs and diseases were retrieved using Venny, intersecting targets were constructed using String to build a PPI network, and a drug-component-disease-target network was constructed using Cytoscape software. Finally, GO function and KEGG pathway enrichment were analyzed for the action target. Results: With 324 important GO biological processes and 56 KEGG signaling pathways, which were mostly involved in inflammation, immunity, and transcription, 56 prospective targets were discovered for the therapy of COVID-19 with licorice-dried ginger soup. Conclusion: licorice ginger soup may treat COVID-19 by interacting with various targets, including STAT3, RELA, IL6, and others.
[Full Text Article] [Download Certificate]