Abstract

Dr. Samriddhi Sharma*, Dr. Shristi Painuly, Dr. Suneel Pal Singh and Dr. Yogesh Kumar

ABSTRACT

It?s an Autoimmune disease. It is insidious in onset, progression to radiological sacroilitis over several years. In this there is mainly a chronic inflammation of vertebras causing severe pain but in advanced cases there can be seen fusion of spinal vertebras primarily affects the axial skeleton. The pathogenesis of AS is poorly understood. Immune mediated HLA-B27, cytokines, inflammatory cellular infiltrates and genetic factor plays important role in this disease. AS is characterized by joint involvement, digits and enthuses, impaired spinal immobility, peripheral arthritis, and postural abnormality. After most of the research it is shown that this disorder has correlation with the histocompatibility antigen HLA-B27 and the interleukin-23/17 axis. Its pathophysiology remains unknown. The beginning of this is progressive and seen as aseptic aggravation at the sacroiliac joints causes decreased personal satisfaction. The most common finding of ankylosing spondylitis is acute foremost uveitis which is found in 20- 25% of patients. AS is discovered worldwide, however, it is increasingly common in Caucasians. Ankylosing spondylitis mainly occure in 45 years of age and has a higher incidence in males then females. This leads to reduce quality of life if not treated properly. Its treatment mainly includes multidisciplinary approach and NSAIDs and in severe cases surgery can be done.this survey article is about ankylosing spondylitis, its pathogenesis, and conclusion. Objectives 1. Identify the etiology of Ankylosing Spondylitis. 2. Review the management options available for Ankylosing Spondylitis.