World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

INFERTILITY AND T-SHAPED UTERUS WITHOUT DIETHYLSTILLBESTROL (DES) EXPOSURE: A CASE REPORT AND LITERATURE REVIEW

Richard Ngendabanyikwa*, Amal Benbella, Nouhaila Haoussani, Zakia Tazi, Abdelhay Adib Filali, Mohamed Hassan Alami, Rachid Bezad

ABSTRACT

Despite the frequency of uterine abnormalities in infertile women (40% to 50%), infertility of exclusively uterine origin represents only 2 to 3% of infertility. This is due to the frequent association of uterine lesions with other causes of infertility. These lesions can interfere with spontaneous fertility or affect the results of medically assisted procreation (MAP). 3D ultrasound and MRI are currently the techniques that have demonstrated the best results in terms of sensitivity and specificity. A Metroplasty is a surgical intervention which aim to restore normal uterine anatomy in certain uterine malformations, with a goal to improve the obstetrical prognosis. Enlargement metroplasty certainly has a positive impact on the outcome of reproduction in patients with uterine hypotrophy and/or dysmorphism, particularly in women who have been exposed to Diethylstilbestrol (DES) in utero. However, there is a lack of Evidence to offer this intervention as a first-line therapy, apart from specific cases such as elderly nulligest or before inclusion in medically assisted procreation (AMP).

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