Abstract

Azhar Mahdi Abed Alamer*, Israa Saeed Abbas and Riadh Abd ALrasul Hnewa

ABSTRACT

Introduction and aim: Septicemia, or sepsis, is the clinical name for blood poisoning by bacteria. It is the body's most extreme response to an infection. Sepsis that progresses to septic shock has a death rate as high as 50%, depending on the type of organism involved. sepsis can quickly lead to tissue damage, organ failure, and death. Several causes of infection, including parasites, bacteria, fungi. In this study include, One hundred (100) participants were enrolled in this study including three groups involved in this case-control study according to clinical diagnosis. The purpose of the present study is to find the effect some biomarker on sepsis patients like acute phase reactant proteins and HS.troponin and Pro BNP, albumin, prealbumin, ?1-acid glycoprotein ,C-reactive protein, ?1-antitrypsin, haptoglobin and fibrinogen, also to identified the common type of bacteria that occur in septic patient.This atudy conducted in the Imam Hussein hospital in Center ICU & Imam Zain Al-Abdeen hospital during the period from October 2022 to May 2023. Materials and Methods: A case-control study of patients with septicemia was conducted. In the Imam Hussein Center ICU/ Imam Zain alabdeen hospital during the period from October 2022 to May 2022.in Karbala city. Results: In this study found that ( serum amyloid A ) of the patient groups (A &B) for neonate and adult(mean ±SD) (33.91±17) (39.5± 27.76) (28.35±23.97) (27.76±20.62) significant higher than control groups (C) (mean ±SD) (5.38±5.12) (5.9±6.48) respectively at level P value (< 0.05),and there is no significant differences between adult and neonate in different groups. Show table(1). In this study found that (Fibrinogen) of the patient groups (A &B) for neonate and adult (mean ±SD) (413.5±98.42) (489±76.36) (434.35±168.11) (440.76±154.95) significant higher than control groups (C) (mean ±SD) (334.97±102.38) (306.31±136.99) respectively at level P value (< 0.05),and there is no significant differences between adult and neonate in different groups show table(2). In this study found that ( HS-Troponin) of the patient groups ( A &B) for neonate and adult(mean ±SD)( 4.9±1.3)( 7.6±1.4)( 6.11±42.26) (5.20±38.67) significant higher than control groups (C) (mean ±SD) (0.95±0.3) (1.1±0.08) respectively at level P value (< 0.05),and there is no significant differences between adult and neonate in different groups show table (3). Conclusion: the routine hematological technique (CBC)and some of biomarker as (SAA _HS-Troponin _Fibrinogen) could use routinely to diagnosis of sepsis and this marker unreliable to assess the severity of disease, and gold stander for diagnosis is blood culture.