World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

HAEMOPHAGOCYTIC SYNDROME: AN ENTITY NOT TO BE INGESTED IN ACUTE HEPATIC FAILURE

Loubna Dehou*, Hakima Abid, Nada Lahmidani Mounia Elyousfi, Mohammed El Abkari, Adil Ibrahimi and Dafr Allah. Benajah

ABSTRACT

Haemophagocytic Syndrome (SAM), whether genetic or acquired, is a clinico-pathological entity characterized by an excessive and uncontrolled inflammatory response, which can be life-threatening. The liver is an important target organ: hepatomegaly is found in half of patients, hepatic biological damage is present in 75% of cases. The appearance and/or worsening of cholestasis is an element of poor prognosis in this situation. The liver biopsy is informative in making the diagnosis of SAM and finding the etiology when it is an acquired SAM. The clinical spectrum ranges from mild SAM which resolves with treatment for the triggering etiology, to rapidly fatal SAM in the absence of specific treatment. The frequency of this syndrome is probably underestimated in the gastroenterology department. Haemophagocytic syndrome should be suspected in patients with fever and jaundice without infection.

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