Abstract

Rahul Sharma, Rupesh Choudhary, Divya Drishti* and Ankita Jamwal

ABSTRACT

Background: Functional dyspepsia (FD) is a condition characterized by a variety of gastrointestinal symptoms, such as abdominal pain, bloating, nausea, and early satiety, without any clear structural or biochemical cause. There are several treatment options available for managing dyspeptic symptoms, including replacing NSAIDs with COX-2 inhibitors, proton pump inhibitors, and treatment of H. pylori infection. Refractory cases can be treated with antidepressant or prokinetic drugs. Methods: The study evaluated the efficacy of levosulpiride in managing dyspeptic symptoms and found it to be as effective as cisapride but with better tolerability and milder adverse effects. Levosulpiride also improved gastric and gallbladder emptying, gastrokinetic activity, and glycemic control in diabetic gastroparesis. Result: Levosulpiride was found to be an effective treatment for dyspeptic symptoms, improving symptoms and quickening gastric and gallbladder emptying, with mild adverse effects, and without serious cardiovascular adverse effects. Conclusion: Levosulpiride is an effective and safe treatment option for managing dyspeptic symptoms, improving gastric and gallbladder emptying, gastrokinetic activity, and glycemic control in diabetic gastroparesis. It has better tolerability and fewer adverse effects than other agents, with common adverse effects like galactorrhea, somnolence, fatigue, and headache improving gradually without discontinuation of treatment.