Abstract

J. Ouchraa*, K. Harou, H. Asmouki and A. Soumani

ABSTRACT

Pemphigoid Gestationis (PG) is a rare autoimmune dermatosis related to pregnancy, with an incidence of 1 in 20,000 to 50,000 pregnancies. it usually appears during the second and third trimesters, but can also occur at any stage of pregnancy and postpartum. Clinical manifestations of PG include intense pruritus, papules and annular plaques followed by vesicles and finally large, tense, bullae on an erythematous background that typically appear periumbilical and spread to the trunk and extremities. The diagnosis of PG is based on a deep clinical evaluation, the histological findings, direct and indirect immunofluorescence and the measurement of serum levels of anti BP180 antibodies using ELISA. PG can have an impact on pregnancy by increasing the risk of intrauterine growth restriction, prematurity and obstetric complications. We report the case of a 36-year-old multigravida, diagnosed with Pemphigoid Gestationis, in week 26 of gestation. The patient was treated successfully and delivered a healthy child without any symptoms of congenital pemphigus.