Abstract

Naba HaiderAli*, Shaymaa Z. Nada and Maha Fadhil Smaism

ABSTRACT

Background: Polycystic ovarian syndrome is a common inflammatory endocrine disorder that affects women of reproductive age and considered risk factor for infertility. Visfatin is an adipocytokine known as pre-B cell colony-enhancing factor expressed in a variety of tissues including adiposities, lymphocytes, bone marrow, liver, and muscle. Visfatin binds to insulin receptor and exhibits insulin-mimetic actions; therefore, it stimulates glucose uptake in adipocytes and muscle cells and suppresses glucose release from hepatocytes. It is now believed that visfatin action can be endocrine, paracrine, and autocrine as well. These autocrine effects of visfatin may play an important role in regulating insulin sensitivity in the liver. Aim: This study aims to investigate serum visfatin level among Iraqi women with PCOS and control to detect any relation as a predicator for PCOS pathogenesis and its association with age, BMI and insulin resistance. Materials and Methods: This study is a case-control study involves (120 women) with age ranged between (20-40) years and their BMI between (20-35) kg/m². Sixty samples with PCOS patients and another 60 are non-PCOS women as a control group collected during Dec., 2021 to April, 2022 from child-bearing age at the reproductive fertility consultant of gynecological and obstetric teaching hospital, Babylon Health Directorate, Babylon- Iraq. The ethical agreement was obtained from a committee at college of medicine, university of Kerbala / Kerbala – Iraq. The Rotterdam criteria were applied to select the PCOS patients. Controller group have regular menstruation, with normal ovaries as they were detected by the gynecologist. Five ml of blood was drawn and but in gel tube to measure serum (Endothelin-1, visfatin, LH, FSH, free testosterone levels) in cycle day two (CD2). Lipid profile (total cholesterol TC, high density lipoprotein HDL-C, low density lipoprotein cholesterol, LDL-C, very low density lipoprotein VLDL and triglyceride TG) were determined. Insulin, HOMA-IR and blood glucose were also determined. Results: The mean levels of biomarkers among infertility groups in women with PCOS shown that all parameters were significantly differed among the groups (p values