BIOCHEMICAL AND HISTOMORPHOLOGICAL EVALUATION OF AGERATUM CONYZOIDES ON ALUMINIUM CHLORIDE INDUCED HEPATOTOXICITY IN A RAT MODEL
Arhoghro Ejovwoke Marcellinus*, Beredugo Sylvanus and Berezi E. Peter
ABSTRACT
Aluminium is a hazardous heavy metal in the environment and accumulates intissues of humans and may cause health problems. Ageratum conyzoides is an herb used in traditional medicine in several countries of the world. This study evaluated the protective potential of Ageratum convzoides on oxidative stress mediated hepatoxicity following aluminium chloride administration. Twelve (n=12) male albino rats were assigned randomly into 3 groups of 4 animals each. Group 1 served as negative control and received pelleted growers feed and distilled water ad libitum. Group 2 served as positive control and was induced with 100mg/kg body wt. of aluminium chloride (AlCl3). Group 3 received 100mg/kg body wt. of aluminium chloride and 100mg/kg body wt. of Ageratum convzoides extract as treatment. All treatments were given orally and lasted for a period of fourteen (14) days. The results showed that MDA and ALT concentration increased significantly (p
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