World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

TESTICULAR TOXICITY INDUCED BY CYCLOPHOSPHAMIDE AMELIORATED BY HERBAL EXTRACT (JALIN): AN EXPERIMENTAL STUDY

Arhoghro Ejovwoke Marcellinus*, Berezi E. Peter and Owotgwun Kasirotu Levi

ABSTRACT

This study aimed to evaluate cyclophosphamide induced testicular toxicity ameliorated by herbal extract (Jalin) (Ginseng, Lepediummeyenii, Liriosmaovata and Honey). Fifteen (15) albino male rats were grouped into three (3) and treated with cyclophosphamide and Jalin extract. Distilled water was given to group one, which served as the control. Group two received 100mg/kg bwt of cyclophosphamide per body weight of albino rats and group three received cyclophosphamide 24 hours before the administration of 2ml/kg of Jalin extract per body weight of albino rats. Male reproductive hormones and body weight were measured in blood samples (testosterone, luteinizing hormone and follicle stimulating hormone). Results showed a significant decrease (p

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