ANTI-ANAEMIC AND HYPOLIPIDAEMIC POTENTIALS OF CORN SILK (STIGMA MAYDIS) EXTRACT ON PARACETAMOL-OVERDOSE IN WISTAR RATS
Nwankpa Promise and Uche Mercylyn Ezinne*
ABSTRACT
Aim: The study assessed the anti-anaemic and hypolipidaemic potentials of corn silk (Stigma maydis) extract on paracetamol over-dose in wistar rats. Methodology: Thirty-two albino Wistar rats weighing between 120g-130g were divided into four groups and used for the study which lasted for 21 days. Group 1 animals which served as the positive control were given normal rat feed and water daily. Group 2 animals received a single dose of 600mg/kg/day of paracetamol in addition to normal rat chow and water. Group 3 received a single dose of 600mg/kg/day of paracetamol + 100mg/kg of ethanol extract of corn silk daily while group 4 received 600mg/kg/day of paracetamol + 200mg/kg of ethanol extract of corn silk daily. All administrations were done orally. After 21 days of treatment, the animals were fasted for 24 hours, euthanized and haematological and lipid parameters were measured. Results: Results showed a significant increase (p
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