Abstract

Dr. Antony Jacob, Dr. Anakha Kaladharan*, Dr. Shajahan O. M. and Dr. K. Mukesh

ABSTRACT

Background: Chronic renal failure (CRF) is a permanent decline in renal function caused by the renal tissue's defective functioning. The resulting weakening of the kidney's excretory, metabolic, and endocrine functions leads to the development of the uremia clinical syndrome. Aim and Objective: A study of patients with chronic renal failure was carried out to analyze the changes in different lipoprotein fractions. Methods: 50 Cases of chronic renal failure were taken for study. These patients were divided into two groups. One group consisting of 25 Patients who were on conservative treatment, and the other group of 25 patients were on regular short term hemodialysis (6 months - 2 years). Cases of chronic renal failure admitted in the medical wards of Vinayaka Mission Kirupanandha Variyar Medical College and Hospitals, Salem from April 2015 to April 2016 were taken for study. Results: CRF patients had significantly higher plasma triglycerides, LDL, and VLDL fractions than controls. In CRF patients, plasma HDL levels were significantly lower than in controls. In terms of total cholesterol, there was no significant difference between CRF and controls. The ratio of HDL to total cholesterol was lowered significantly. Conclusion: Both conservative and hemodialysis CRF patients had excess triglycerides, LDL, and VLDL. Both conservative and hemodialysis CRF groups had reduced HDL cholesterol. HDL-to-total cholesterol ratio dropped. Hypertriglyceridemia causes atherosclerosis. Proper treatment of uremic dyslipidemia is crucial for preventing or postponing cardiovascular complications in CRF patients.