World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

IMMUNOGLOBULIN AND COMPLEMENT LEVELS IN LIVER CIRRHOSIS AND OVARIAN CANCER ASCITES PATIENTS

Md.Khaleel Pasha*, M.Gopal Reddy, B.Ramesh Kumar, M.Srinivasulu, K.Suseela, Qamar Ayesha, Gita Sharma and Livy Alex

ABSTRACT

The pathological accumulation of abdominal fluid is due to multiple causes often associated with either peritoneal or non-peritoneal diseases. Cirrhosis of liver is a chronic disorder, where ascites develops in advanced stages with alteration in humoral and innate immunity where as in ovarian cancer most of the cases ascites develops in the early stages after the onset of the disease.The aim of this study was to estimate the concentrations of serum and ascitic fluid immunoglobulins (IgG, IgA, IgM) and complement components (C3, C4) levels in ascitic patients with liver cirrhosis in comparison to ovarian cancer and if significant differences are found, our question was, could it be used for screening. The present study was performed on 170 ascitic patients with liver cirrhosis, 95 ovarian cancer and 100 healthy serum samples served as normal controls. The study showed significantly increased levels of serum IgG, IgA and grossly decreased levels of complement C3 and C4 in liver cirrhosis patients when compared to ovarian cancer and controls (p

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