World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

FORMULATION AND EVALUATION OF MULTIPLE EMULSION OF NADALOL

*Abul Hasham, Shabana Parveen, G. Durga Bhavani, Jubayer Mehbub Jinnah, K. Sindhu Madhuri and
K. Jeevan

ABSTRACT

Multiple emulsions have been proposed to have numerous uses including their use for enhancement of bioavailability or as a prolonged drug delivery system. But the inherent instability of this system needs to be overcome before they find potential application in pharmaceuticals. Multiple emulsions are often stabilized using a combination of hydrophilic and hydrophobic surfactants. The ratio of these surfactants is important in achieving stable multiple emulsions. Nadalol was selected as a model drug to study the potential of multiple emulsion to improve bioavailability with the hypothesis that improvement of drug release profile will reflect the enhancement of bioavailability of the drug. The objective of this study was to prepare multiple emulsion of Nadalol by two step emulsification using different nonionic surfactants, Tweens & Spans, and evaluate for stability, percentage drug entrapment, in vitro drug release. The study concluded that stable multiple emulsion with high entrapment efficiency can be prepared by two step emulsification method using Spans40, 60, 80 as primary emulsifier and Tween80 as secondary emulsifier.

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