Abstract

Maysoon Sharief, D.O.G., C.A.B.O.G.*, Ghufran Jaafar, D.O.G., C.A.B.O.G. and Hanan Awad, M.B.Ch.B.

ABSTRACT

Background: Women with polycystic ovarian disease are labile for medical problem in regard to cardiovascular system and more liable to have diabetes mellitus. C-reactive protein (CRP) can be strong marker of future CVD. Objective: To determine whether there is an increased level of serum CRP and white cell count and their related factors in women with ovarian polycystic ovaries. Patients and Methods: case- control research which was conducted in Basrah Maternity Hospital. 116 women (26.5 ± 8 years) with PCOS were recruited from Basrah infertility center. The control group (31.5 ± 8 years) involved 94 fertile women who attend Gynecological and Obstetrical. Serum level were collected from patients and control groups. Hormonal estimation of both gonadotropin, estrogen, prolactin, thyroid stimulating hormone, free thyroxine, and serum blood sugar were measured. A lipid profile, complete blood picture and C-reactive protein (CRP) were estimated. Transvaginal ultrasound was done to all the participants. Results: The high level of CRP among women with PCOS was 36.8% in comparison to the control group. The body mass index, thyroid stimulating hormone, prolactin, serum blood sugar, lipid profile levels were not significantly different between the 2 groups while LH and estradiol were significantly different (P <0.001). White blood count was significantly more in the patient group compared with the control group. There is statistical significance between the patient and the normal group with high body mass index ( > 30 Kg/ M 2) and the same observation in both group with other BMI ( <25, 25-29 Kg/ M 2). Conclusion: It observed from the study that women with polycystic disease had high level of white cell count and CRP concentrations, which may suggested that women with polycystic ovarian is associated with low-grade inflammation.