MONITORING THE ACTIVATION OF IMMUNE RESPONSE IN FAMILIAL MEDITERRANEAN FEVER AMONG EGYPTIAN PATIENTS
Mai A. EL-Sobky*, Osama Kamal Zaki, Abdel-Rahman B. Abdel-Ghaffar and Magdy M. Mohamed
ABSTRACT
Background: Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder characterized by seemingly unprovoked recurrent episodes of fever and serosal, synovial, or cutaneous inflammation (Djouher Ait-Idir et al., 2017). It is mainly diagnosed clinically and the most widely accepted criteria for diagnosis of typical cases is the Tel Hashomer criteria (Ryan et al., 2010). Methods: Tests used to diagnose 40 patients with FMF disease clinically include physical exam, review of your family medical history; serological tests such as total Leukocytes Count, fibrinogen, erythrocyte sedimentation rate serum Amyloid A protein, C-reactive protein and Cytokines (IL-10, 1L-1B), and molecular analysis of mutations with strip test technique. Results: This study revealed that the most common mutations were M694I (26.4%), E148Q (20.8%), V726A (17.0%), and M680I (G/A) (17.0%). The CRP levels (mg/dl), Fibrinogen (mg/L), Amyloid A protein (mg/L) as well as ESR (mm/hrs.) increased comparing to the baseline level by the values 633.64%, 303.82%, 1258.78%, and 500.2% (p
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