World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

COMPARISON OF THE RECOVERY PROFILE OF HYPERALGESIA EVALUATED BY THREE DIFFERENT METHODS AND EFFECTS OF INTRATHECAL MORPHINE IN POSTOPERATIVE PAIN MODEL OF RATS

*Dr. Tomoki Nishiyama MD, PhD

ABSTRACT

Background: We compared the effects of paw incision, intrathecal single or repeat morphine administration on three different tests of hyperalgesia using a rat model to know the characteristics of these tests. Methods: Male Sprague-Dawley rats with lumbar intrathecal catheters received a 1 cm longitudinal incision through skin and fascia of the plantar aspect of the foot followed by suture. Von Frey filament withdrawal weighting, thermal withdrawal latency, and weight bearing were evaluated for postoperative 7 days. The effects of single intrathecal morphine after surgery and repeat intrathecal morphine every day on the three methods were also studied. Results: Paw incision decreased Von Frey withdrawal weighting, thermal withdrawal latency, and weight bearing only on the operated paw. In these methods, Von Frey withdrawal weighting and thermal withdrawal latency gradually returned after 2 hours, but not to the control levels on 7 days. Single intrathecal morphine recovered Von Frey withdrawal weighting and thermal withdrawal latency dose dependently, but not weight bearing. Repeated intrathecal morphine every day induced similar recovery with single intrathecal morphine in the Von Frey withdrawal weighting, and better recovery in the thermal withdrawal latency. Conclusions: To study postoperative analgesia in a rat paw incision model, weight bearing showed different results compared to Von Frey withdrawal weighting and thermal withdrawal latency. Repeated intrathecal morphine every day after surgery induced better recovery of thermal hyperalgesia but not of tactile mechanical hyperalgesia than postoperative single intrathecal morphine.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR