Abstract

Gayathri Devi K.V. and Dawn V. J.*

ABSTRACT

Statins are the gold standard for the prevention of primary and secondary CVD events, which is a leading cause of mortality worldwide. Because of this, statins are the most widely prescribed drug. But as the use of statin-use increased, patients began to experience many difficulties. After conducting several studies based on this, we have come to know that it has side effects along with the long term and intensive use of statins. One of the main side effects is statin-induced new-onset diabetes. It is well established by several studies that statins may induce new-onset diabetes in patients. Intensive-dose statins are the most to induce diabetes as compared to moderate-dose statins. There are several mechanisms behind statin-induced diabetes. Mechanistically, statins inhibit the HMG CoA reductase enzyme in the cholesterol biosynthesis pathway. By this process, it will affect pancreatic ?-cell leads to a decrease in insulin release. And also statin use enhance the resistance to insulin in adipocytes, muscles and liver because statin alters insulin sensitivity in these areas. This is how statin causes diabetes. However, statin is an indispensable drug for preventing CVD events. Therefore, statins are still recommended to continue for reducing cardiovascular disease event risk in appropriate patients with and without diabetes or risk factors for diabetes.