Abstract

Rashad M. Kaoud*, Eman J. Heikal and Lina M. Jaafar

ABSTRACT

The term "Nanogel" refers to a hydrogel nanoparticle with a network of cross-linked hydrophilic polymers. Nanogels are nanoparticles made up of cross-linked polymer that expand in a suitable solvent. For polynucleotide delivery, cross-linked networks of a poly ion, a nonionic polymer (cross-linked polyethyleneimine (PEI) and poly (ethylene glycol) (PEG). The creation of Nanogel systems that have proven their ability to deliver drugs in a sustained, controlled, and targetable manner has been necessitated due to the sudden explosion in the field of nanotechnology. As clinical trials progress, it is now unavoidable to develop smart nano-systems that can be used for treatment due to the growing field of polymer sciences. The goal of this brief review is to provide comprehensive examples of novel Nanogel applications, drug loading techniques, and drug release mechanisms. Furthermore, the current state of Nanogels, the status of clinical trials and future prospects have been summarized.