Abstract

Mahaveeraswamy B. M., Bhagawathi S. T.* and Manjunath K.

ABSTRACT

An objective of the hypertension treatment is to suppress the blood pressure in a faster onset of action. This is generally achieved by drug to be administers directly into the blood circulation through the Buccal mucosa by using fast dissolving strips formulation. The drug to be administered in the Buccal route through GIT it can be metabolized more for this reason drug can be administered in the Buccal mucosa by using strips formulation give fast onset of action. The objective of this research work was to improve the bioavailability of the drug and fast the onset of action to decrease the blood pressure. The Buccal bioavailability of Doxazosin mesylate is only 60% for this reason drug can be administrated into Buccal mucosa using mucoadhesive strips. Fast dissolving Buccal strips were prepared by solvent casting method using various polymers like hydroxyl propyl methyl cellulose E15, PVP K-30, PVA and Glycerol as plasticizer and saccharin as a sweetening agent and vanillin as a flavoring agent. Dissolution profile as studied in a USP dissolution apparatus type 1 using a pH 6.8 simulated saliva. The influence of variable like polymer type, concentration, of Doxazosin mesylate release profile was studied. The formulation was optimized on the basis of various evaluation parameters like drug content and in vitro drug release. Formulation F6 successfully fast the release of drug within 8 minutes.