Abstract

*Khadija Benchekroun, Sawsane Razine, Siham Lemsaness, Soukaina Harrak, Saad Lannaz, Pr Ibrahim Elghissassi, Pr Hind M’rabti, Pr Saber Boutayeb and Pr Hassan Errihani

ABSTRACT

Background: Malignant transformation of a mature cystic teratoma (MCT) is a rare complication that occurs in 0.17% to 2% of cases in usually postmenopausal women. The most common form of malignant transformation of a MCT is squamous cell carcinoma, accounting for more than 80% of malignant transformations. The frequency of malignant transformation of MCT to adenocarcinoma is just 6.8%. Case presentation: We report two Moroccan cases of mature cystic teratoma with two different malignant transformations arising from it; the first case was transformed into mucinous cystadenocarcinoma and the second into squamous cell carcinoma (SCC). Our both cases presented the same symptoms, including chronic abdominal pain and distention. The two patients underwent a complete staging surgery, the patient of case 2 required adjuvant chemotherapy given a positive peritoneal cytology unlike the patient of case 1 which was classified as stage IA and close follow-up has been proposed. To date, the two patients have not presented a recurrence of the disease during the past 4 years of follow up. Conclusion although the prognosis seems highly dependent on the stage of the disease, there is a lack of consensus in the literature regarding adjuvant treatment. In light of adjuvant Platinum-based chemotherapy used for epithelial ovarian cancer, its use in this kind of situation seems to be a reasonable option with interesting outcomes.