Abstract

*G. Mary Ratna Anitha, Kanukuntla Sushma, Gade Divya, Ranjith Kumar and Relaker Preethi

ABSTRACT

The purpose of the present study was to formulate solid dispersion incorporated fast dissolving tablet of Resperidone to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Solid dispersion of Resperidone was prepared with various super disintegrants in different drug: carrier ratio using solvent dispersion technique.The objective of the study was to formulate and evaluate fast dissolving tablet of Lamotrigine. Direct compression method was used to formulate orally disintegrating tablet of Resperidone by employing solid dispersion, magnesium stearate (lubricant), Talc (glidant). These prepared formulations were then evaluated. In vitro Dissolution tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. All formulations showed compliance with pharmacopeia standards. The effect of super disintegrant concentration and direct compression method on drug release profile was studied. Release profile of F3were found to be satisfactory comparing to other formulations. F3Formulation as processed excipient was found to be the best super disintegrants for the preparation of Resperidone fast dissolving tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations.