Abstract

Madaram Srinivas*, Dasari Priyanka Reddy, Malyala Shreya Reddy, Lanka Raksha, Nazia Lateef Amrohi

ABSTRACT

Aim and Objective: The main aim of the study is to focus on the prevalence of ESBL and MDR organisms, the sensitivity of antibiotics, its risk factors, and the management of urinary tract infections in a tertiary care hospital. Results of the Study: The study was conducted on 100 UTI patients with positive urine culture and sensitivity reports. It was identified that males and females account for (61%) and (39%) respectively. The most common and least common organisms detected are Escherichia coli with (35%) and Klebsiella species with (1%) respectively. The study among the 100 UTI patient urine cultures reports ESBL and MDRO organisms are identified as (15%) and (11%) respectively. Among the 100 urine culture samples, 15/100(15%) of samples are ESBL producers in which males 11/15(73.3%) and females 4/15(26.6%) the most common age group are 60-80 years 5/15(33.3%). Out of 100 urine culture samples, 11/100(11%) of the samples are identified as the MDR organisms out of which males 8/11(72.7%) and females 3/11(27.7%), and the most common age group are 50-60 3/11(27.7%). The most common organisms of the ESBL and MDRO are Escherichia coli (66.6%) and pseudomonas aeruginosa. (81.8%) respectively. The least common organisms of the ESBL and MDRO are Klebsiella species (6.6%) and (9%) respectively. The sensitivity of antibiotics among the ESBL and MDRO organisms of which most sensitive is colistin accounts (100%) and tobramycin and ceftazidime+ tazobactam which accounts for (1%) and (6.6%) respectively. The most common risk factors for ESBL and MDRO organisms are antibiotic prior use (20%) and recurrent UTI (45.4%) respectively. Conclusion: This study concludes that E. coli and pseudomonas aeruginosa. are the most frequent ESBL producers and MDR organisms respectively. Also identified that only antibiotics sensitive to MDR organisms are colistin and polymyxin-B. Hence health care providers should review the current guidelines used for empirical and effective treatment of ESBL and MDR organisms and prescribe antibiotics only if needed and also should recommend completing the antibiotic course completely.