Abstract

Sèdagbandé Stanislas Pendélakys Gbètognon*, Irie Bi Jean Severin, Osseni Razack and Abo Kouakou Jean-Claude

ABSTRACT

Sorghum bicolor is a medicinal plant used by oral administration. This plant is known in traditional medicine for the treatment of several conditions including anemia. The objective of this work is to evaluate the cytotoxicity on blood cells and acute and subacute toxicities of an aqueous extract of dry leaves of Sorghum bicolor (AESb) administered orally in mammals. The study of the acute toxicity of AESb in Mus musculus (Muridae) – mice – shows that, for up to the maximum dose of 5000 mg / kg BW, this extract does not cause death in treated animals by oral administration. Similarly, the study of the subacute toxicity the AESb shows that this extract administered by gavage for 28 days causes no death in treated rats. In addition, the monitoring of the change in weight during the 28 days of the experiment showed no loss of body mass and no significant difference in the increase in body mass of the rats treated with AESb at doses of 1000, 1500 and 2000 mg / kg BW, compared to controls. In addition, after 28 days of treatment of the rats with AESb at doses of 1500 and 2000 mg / kg BW, no significant change in the relative mass of certain vital internal organs (liver and kidneys) of these treated animals was recorded. Finally, the study of the cytotoxicity of AESb shows that this extract has a protective effect on the plasma membrane of red blood cells in rats. The results obtained in this study suggest that the administration of AESb would not constitute a risk in the pharmacological use of this extract in the treatment of anemia.