Abstract

*Dr. Arfeen Azam Khan, Dr. Sumera Nawaz, Dr. Dara Jamali, Dr. Maria Abid, Dr. Fatiha Iftikhar,
Dr. Shuja Rehman and Mhammad Muzammil

ABSTRACT

Background: Urinary tract infections, in our environment most commonly caused by E.coli. Common regimens include trimethoprim silfamethoxazole, cephalosporins, floroquinolones, nitrofurantoin and aminoglycosides. Over the period of time the sensitivity pattern is expected to change and hence continuous research should be undertaken to establish the changed sensitivity of E.coli to different antibiotics. Objective: To determine the antibiotic sensitivity of Escherichia coli in urinary tract infections to Ampicillin, Ceftazidime, Nitrofurantoin and Gentamycin. Study Design: It was an observational study,analyzing urine cs reports ast a particular time. The study was cross sectional. Setting: The department of Medicine, Ziauddin Medical University & Hospital, Karachi. Duration: From 2nd June to 1st December 2016. Material and Methods: Total 206 samples were taken. Once sample showed E.coli growth, the patients were approached to acquire relevant data and sensitivity report given by the laboratory was studied, after which descriptive statistics were calculated and stratification was done. Chi square test(X2) was used after considering value of P less than 0.05 as significant. Results: There were 224 patients in total out of which 82 were men and 124 were women. Mean duration of illness was 9.54±5.94 days. The sensitivity pattern of E.coli with ampicillin was 7.3%, ceftazidime was 19.9% sensitive, nitrofurantoin was 92.7% sensitive, and gentamycin was 30.6% sensitive. Ampicillin was significantly associated with genderwhereasnitrofurantoin with duration of illness. Conclusion: E.coliwas the predominant uropathogen and its antibiotic sensitivity should be considered for starting antibiotics empirically for urinary tract infections Highest sensitivity 92.7% was observed with Nitrofurantoin.