Abstract

Reshma Mohan M., Daisy P. A.*, Praveen Raj R., Boby Johns G., Noby Thomas and Betty Carla

ABSTRACT

In the current scenario targeted drug delivery requires an efficient drug carrier which can deliver the drug specifically on the site of action in a sustained and controlled manner. Among many such carriers, microspheres fulfil all the parameters for a potent drug carrier. Microspheres are one of the multiparticulate delivery system which is prepared to obtain prolonged or controlled drug delivery. Microspheres are defined as free flowing powders of spherical shape, consisting of proteins or synthetic polymers, which are either biodegradable or nonbiodegradable in nature and ideally having a particle size ranging from 1–1000 ?m. The internal structure of the microspheres can vary as a function of the microencapsulation process employed. Controlled drug release from microspheres occurs by diffusion of the drug through a polymeric excipient, diffusion of the entrapped drug through the pores in the polymeric microspheres.