Abstract

Sheth Nishi* and Dr. Hemraj Singh Rajput

ABSTRACT

A Werner’s syndrome also known as premature aging syndrome is a rare autosomal recessive disorder caused by genetic change in WRN gene. In this case, a 27-year-old male patient came to a multispecialty hospital with complaints of loss of hair, skin lesions over body with itching, loss of weight, loss of appetite, urinary hesitancy, ulcers in mouth, inability to eat, and difficulty in walking. On examination, multiple hyperkeratotic plaques with scaling all over body with itching, multiple depigmented patches extending to feet, whitish deposit seen over tongue, flat feet, short stature, greying and balding (alopecia) were found to be similar with Werner’s syndrome. Patient is diagnosed with PEM (protein energy malnutrition), nutritional anaemia and alopecia universalis. Werner’s syndrome is not curable, only symptomatic treatment is provided. This case report provides an insight of Werner’s syndrome and its pharmacotherapy on symptomatic basis according to hospital admission guidelines. Early recognition will help for the further complications related to Werner’s syndrome and helpful for the further consequences.