Abstract

*Dr. İrem Akın Şen, Dr. Özlem Tiryaki and Dr. Cem ŞEN

ABSTRACT

Background: Vitamin D deficiency is frequently seen in the studies performed on kidney transplantation patients. This study, aimed at comparing the influences of active vitamin D therapy on the proteinuria and glomerular filtration rate (GFR) in kidney transplant patients. Methods: The patients were divided into two groups: patients having parathormone (PTH) level >400 pg/ml, no diabetes and kidney transplantation and patients with PTH level < 400 pg/ml. The first group received 25 ?g of active vitamin D /day. Vitamin D, complete blood count, biochemical parameters and used immunosuppressive drug levels (steroid, tacrolimus) were recorded for all patients. The patients underwent the active vitamin D therapy for six months, once in every 15 days. Vitamin D was serologically studied through the HPLC (high-performance liquid chromatography) method. Results: The proteinuria level baseline values of the patients getting the active vitamin D therapy were 158.09±58.84 mg/day in the 0th month and 123.32±51.74 mg/day in the 6th month (p: 0.02). These values were 124±22 mg/day and 122±23.1 mg/day in the control group, respectively. The baseline values of GFR levels for the patients getting vitamin D therapy were 67.59?26.13 ml/min/1.73m2 in the 0th month, 76.45±14.23 ml/min/1.73m2 in the 6th month, and the p-value was 0.000 when it was considered in terms of the glomerular filtration rate. These values were 95?14 and 96?12.2 in the control group, respectively. While vitamin D baseline values were 8.6±6.2 ng/ml when it was evaluated in terms of vitamin D levels, vitamin D was found as 19.14±7.02 ng/ml in the 6th-month control (p: 0.0000). These values were 23.03±8.98 ng/ml and 21.02±6.78 ng/ml in the control group, respectively. While a negative correlation was determined between vitamin D level in the patients getting the active vitamin D therapy and proteinuria (p