DEVELOPMENT OF DIFFERENT SPECTROPHOTOMETRIC TECHNIQUES FOR GEMIFLOXACIN MESYLATE AND CEFDITOREN PIVOXIL QUANTIFICATION IN BULK AND COMMERCIAL FORMULATIONS
Salma Ali Al-Tamimi*, Abeer Zail Shebib and Fatma Ahmed Aly
ABSTRACT
Background: The current study aims to suggest three different accurate spectroscopic approaches to quantify gemifloxacin mesylate (GFX) using aluminum chloride (Method A and B) and cefditoren pivoxil using cerium (IV) sulfate (Method C). Methods: The methods are conducted by reacting aluminum chloride with gemifloxacin mesylate in alkaline medium of borate buffer pH 8 and cefditoren pivoxil (CFP) using cerium (IV) sulfate the absorbance was recorded at 270 and 509 nm, respectively. Results: Linear relationships were observed by using 1-10 and 2-24 ?g mL-1for GFX and 2-14 ?g mL-1 solutions for CFP. The estimated quantification limits were 0.281, 0.577 and 0.533 ?g mL-1 whereas, limits of detection values were 0.093, 0.191 and 0.176 ?g mL-1 for the three suggested approaches, respectively. All experimental conditions, including the optical properties were studied. Conclusion: The suggested methods can be exploited in the routine analysis of the studied analyts in their pure and commercial products and also for quality control of both drugs.
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