World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

DEVELOPMENT AND VALIDATION OF SIMPLE UV-SPECTROPHOTOMETRIC METHOD FOR QUANTITATION OF DIAZEPAM IN API AND SOLID DOSAGE FORMULATION

Dr. Shabana Naz Shah*

ABSTRACT

A very simple, accurate, precise, versatile and least economic UV spectrophotometric method for the quantitation of Diazepam in Active Pharmaceutical Ingredient and tablet dosage formulation have been developed using absorbance ratio method and validated as per ICH guidelines. In present study the absorbance values at 285nm were used for the estimation of diazepam. The results of analyses have been validated statistically for linearity, accuracy, precision, LOD and LOQ. The method was found to be linear in concentration range of 2-24 ?g mL-1 with correlation coefficient 0.9997 for diazepam. The results of validation parameters also indicated that proposed method was found to be accurate, precise, reproducible, sensitive and suitable for routine quality control analysis for estimation of diazepam in API and solid dosage formulation.

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