World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301

ICV : 78.6



Shraddha Nagpure*


The aim of present work was to prepared and characterized Metformin Sublingual tablet by using superdisintegrants to increase the rate of Disintegration and Dissolution. Metformin sublingual tablet is prepared by using 3×3 factorial design. The Superdisintegrants like Cross povidon, Polyvinyl pyrrolidon and Microcrystalline cellulose were used in different concentration in each formulation which increase the bio-availability of formulation. All formulations were prepared by Direct compression method. The prepared F1 formulation is the found to be best formulation among all 9 formulations of improving solubility of drugs and prepared Metformin Sublingual tablets were evaluated for weight variation, thickness, hardness, drug content, disintegration and dissolution rate studies. The F1 formulation was found to be 8 sec of disintegration time and 12 min of dissolution time. The developed sublingual drug delivery of Metformin sublingual tablet was one of the alternative route of administration to improve bioavailability through sublingual mucosa and improve patient compliance.

[Full Text Article]

Powered By WJPMR | All Right Reserved