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World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301

ICV : 78.6



Dr. Gitika Arya Agrawal*, Dr. Sakshi and Dr. Subhash Upadhyay


Ayurveda postulates the unique principals of Tridosha, Dhatu and Mala for homeostasis of the body. Dhatu nourishes the body, supply nutrients to other vital tissue, supports the body and keeps the body healthy. During formation of Asthi Dhatu or Bone, Vata creates spaces in bones. These spaces are filled with nourishing tissues of Medas or fat which is known as Majja or Bone marrow. Majja Dhatu is the second last Dhatu formed as - unstable(poshaka) Asthi Dhatu flows through the MajjaVaha Srotas into the Majja Dhara Kala and is digested by the Majjagni. Majja Dhatu nourishes body, strengthens body, fills bones and nourishes Shukra Dhatu. Due to Pragyaparadha, Asatmyendriyarth Samyoga and Parinama, the equilibrium of Doshas, Dhatus and Malas is disturbed and homeostasis in the body is altered. When Majja Kshaya takes place due to disturbed equilibrium of Tridosha then Asthi Dhatu is most affected, because Asthipuranam is done by Majja Dhatu. Asthi Saushirya, Asthi Daurbalya, Asthi Laghuta, Asthi Nistoda, Pratatm Vata Roga, Alapshukrata, Bhrama, Timir Darshnam etc. occur in MajjaKshaya. The symptoms of Majja Kshaya can be correlated in Modern Science with osteoporosis, vertigo, hollowness and lightness in bones and oligospermia etc.The management of Asthi-Majja related diseases is unique because of the Ashrayaashrayi relationship of Vata Dosha and Asthi Dhatu which is fundamental base to understand any pathological condition related to Majja Dhatu. Thus this review study gives complete glimpse of knowledge about every aspect of Majja Dhatu and its vitiation effects described in Classical texts.

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