Abstract

*Rida Javaid, Hafsa Maryam, Asad Atta Qureshi

ABSTRACT

Objective: This study's main objective was to determine the tuberculosis sensitivity pattern for the first line of antibiotics. Place and Duration of Study: This study was conducted in Nishtar hospital Multan's Pulmonology department in 10 months between May 2019 and February 2020. Type of Study: Cross-sectional. Materials and Methods: Patients who were selected were older than 15 years without gender discrimination. Patients who had already used ATT were included in the exclusion criteria. For six weeks, the LJ medium was used for sputum analysis. Mycobacterium sensitivity was analyzed at the first antibiotic line. The standard doses used for LJ medium for sensitivity control were two mcg streptomycin, 100 mcg pyrazinamide, 0.2 mcg isoniazid, five mcg ethambutol, and one mcg rifampicin. Results: This study included a total of 115 cases. 72 (62.60 per cent) of these patients were males. Patients' average age was 35 years. Thirty-six (32.17%) drug resistance was observed, and in some cases, more than one drug was seen. Streptomycin was the most common medicine with resistance from Mycobacterium and included 19 (16.52%) cases. The second most common cause was isoniazid, with 17 (14.78 per cent). Resistance to only one drug was observed in 30 (26.08 per cent). Only 2 cases demonstrated resistance to 3 and 4 antibiotics. Conclusion: Almost every third case is TB resistant, and the highest resistance in streptomycin is observed.