World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

THE STUDY OF COMPARISON OF DIFFERENT CHELATION TREATMENTS FOR THE PATIENTS OF THALASSEMIA

*Rida Ali, Arooj Saqib Malik and Muhammad Hasnain Bashir

ABSTRACT

Objective: To compare different therapies of chelation used for thalassemia based on effectiveness. Place and Duration: It was conducted from 1st May 2019 to 30 April 2020 in DHQ Teaching Hospital, Sargodha. Materials and Methods: The study included 80 thalassemia patients, divided into two groups of 40 patients. Deferiprone was given orally in Group 1, while deferoxamine was injected in Group 2. Results: The average age of the patients was 20.3 ± 4.3 years. Of 80 patients, 54 were male (67.5%) and 26 were female (32.5%). The average ferritin of all patients was 2645 ± 1260, whereas Group 1 was 2545 ± 1232 and for Group 2822 ± 1235. In both groups, there was no significant difference in ferritin level (p value=0.232). For patients, complications included 18.2% IGT, 7.8% DM and 28.7% hypothyroidism for all patients with thalassemia. Conclusion: Both therapies showed equal effectiveness in iron load control in patients with thalassemia.

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