PHARMACOVIGILANCE STUDY ON PROTON PUMP INHIBITORS IN ACUTE MEDICAL WARD AT CIVIL HOSPITAL
Mattapalli Srinayani* and Parankusham Vindhya
ABSTRACT
Proton Pump Inhibitors (PPIs) are mostly used in almost all the cases due to patients may suffer with hospital induced excess acid, Medication induced acid production or Disease itself causing excess acid production. These Proton Pump Inhibitors help in reducing the excess acid production by blocking the H, K-ATPase. But, these drugs though they have good safety profile they may also cause few Adverse Drug Reactions (ADR’s). So, we have conducted a Prospective Observational study for a period of one year and found 152 ADR’s related to PPIs and found mostly prescribed drug among PPIs is Pantoprazole (51%) followed by Omeprazole (34%). Most common ADR found was Urticaria (36.2%) followed by angioedema (21.8%). We have done the severity and preventability assessment and found that most of the ADRs are Mild (51.3%) and Probably Preventable (63%). Based on all these findings we can conclude that Hypersensitivity reactions are commonly occurring due to PPIs. So, Proper monitoring in the initial stage of therapy can reduce the suffering of the patient.
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