World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SUBSTITUTED PHENYL THIAZOLE DERIVATIVES

Prateek Porwal*, Lavkush Tiwari, Sonali Paliwal, Harsh Sharma, Harendra Kushwah and Komal Pal

ABSTRACT

The derivatives of substituted phenyl thiazoles are synthesized from acetophenones and thiourea. The synthesized compounds have been characterized by TLC, elemental analysis, IR,[1] H.NMR spectroscopy. All the compounds were evaluated for anti- inflammatory activity by formalin and carrageenan induced rat hind paw edema method by using nimesulide drug as standard. Nitro substituted thiozole derivatives shows better anti-inflammatory activity when compared to standard drug.

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