Abstract

Eman Abdul Ameer Jabor*, Fadhil Jawad Al-Tu’ma and Wasan Ghazi Al-Safi

ABSTRACT

Background: Risk factors for GDM include obesity, advanced maternal age, type 2 diabetes mellitus (T2DM), family background, prior diagnosis of GDM, recent adverse pregnancy results. At present, the prevalence of GDM is gradually rising, especially in Asia. Highly reactive molecules formed inside the cell are highly reactive oxygen species. Aim: The current study aimed to detect the correlation between the oxidants and antioxidants status determined in gestational diabetes mellitus (GDM) patients in holy Kerbala city, Iraq. Materials and Methods: This study include 46 gestational outside diabetic patients obtained from gynecological and obstetric teaching hospital, Kerbala health directorate / Kerbala – Iraq in addition to 47 women as apparently control group during Nov., 2019 to Sep., 2020 with matched age ranged between 25 – 45 years. The links between oxidative status and gestational diabetic patients were examined. Results: Total reactive oxygen species (TROS) was significantly different between the study groups. It was significantly higher in GDM (70.50 ± 16.01) µmol/L compared to pregnant without GDM (56.05 ± 19.48) µmol/L, with P value (p< 0.05) was 0.002. TAO was no significantly different between the study groups. It was no significant different in GDM (1104.50 ± 464.95) µmol/L compared to control (1201.83 ± 422.58) µmol/L with (P < 0.05). The GDM patients have higher fasting blood glucose, insulin, HMOA, TROS, HbA1c compared with control. There was a positive significant correlation between HMOA-IR and TROS. There was a significant correlation between HMOA-IR and insulin in GDM patient. Non significant association between the parameters studied in the control group except insulin and HMOA-IR. Conclusion: There is a non-significant differences in TAO between control and GDM, TROS was significantly higher in GDM as compared with control. There was strong correlation between HMOA-IR with each of TROS and insulin in GDM patients and control group.