Abstract

Zainab Qassim Abd-Ali, Fadhil Jawad Al-Tu’ma* and Mohamed Tariq Jebir

ABSTRACT

Background: Metabolic Syndrome (MS), understood as a complex set of cardiovascular risk factors, related to abdominal fat accumulation and resistance to insulin, is strongly associated with high cardiovascular mortality. Chronic glucocorticoid (GC) exposure in humans is well known to result in whole-body insulin resistance and obesity. Objective: The aim of this study is to evaluate the effect of biochemical parameters changes such as cortisol in sera of patients with metabolic syndrome and then assessment their correlations with insulin resistance. Materials and Methods: Sample size of the study was 149 persons of both gender selected randomly enrolled in the study which divided into two groups, 80 with metabolic syndrome patients and 69 of apparently healthy individuals as control with their age ranged from (40 to 60) years throughout the period between May. 2019 to Aug., 2020. Results:. There was a significant difference between BMI and biochemical parameters (blood glucose, HbA1c, total cholesterol, TG, VLDL-C, LDL-C, Cortisol) in sera of metabolic syndrome patients and healthy control groups (P ? 0.01). The statistical analysis were used in present study was showed a statistical significant between male and female (P value ? 0.01). Conclusion: There is a significant effect of clinical factors on the incidence and progression of metabolic syndrome disease. There is a significant difference in the cortisol levels between male and female MtS patients.