Abstract

Abduarahman Essadeg*, Abduarahman Amer and Prof. Dr Jovan Popović

ABSTRACT

Kidney transplantation represents the best method of treatment of end stage renal failure. One of the preconditions for successful renal transplantation is the optimal immunosuppressive therapy. The therapeutic goal of immunosuppression is achieveing immune tolerance of the recipients while minimizing unwanted and toxic effects. The combination of immunosuppressive drugs with different mechanisms of action to reduce individual doses of drugs and minimize their side effects, which has great importance for the quality and extension of life of patients with kidney transplants. Optimal selection of immunosuppressive protocol should be harmonized with the individual characteristics of the patient, his primary renal disease, co-morbidities and drug therapy, degree of matching donors and recipients of organs.