Abstract

Ms. Shramika A. Chore*, Dr. Sachin J. Dighade, Ms. Sanjeevani S. Deshkar and Mr. Abhijit Patil

ABSTRACT

Drug delivery systems (DDS) are a strategic tool for expanding markets/ indications, extending product life cycles and generating opportunities. Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. Tablet/Pellets are the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing, however in many cases immediate onset of action is required than conventional therapy. Immediate release solid oral dosage forms are classified as either having rapid or slow dissolution rates. Immediate release dosage forms are those for which ≥85% of labelled amount dissolves within 30 min. Disintegrating agents are substances routinely included in tablet formulations and in some hard shell capsule formulations to promote moisture penetration and dispersion of the matrix of the dosage form in dissolution fluids. In the present case, immediate release may be provided for by way of an appropriate pharmaceutically acceptable diluents or carrier, which diluents or carrier does not prolong, to an appreciable extent, the rate of drug release and/or absorption. Thus, the term excludes formulations which are adapted to provide for “modified”, “controlled”, “sustained”, “prolonged”, “extended” or “delayed “release of drug. Many dosage forms are designed to release the drug immediately or at least as quickly as possible after administration. This is useful if a fast onset of action is required for therapeutic reasons. The general term “granulation” and “pelletization” are sometimes used synonymously, the unit obtained are referred to as granules, pellets, agglomerates or spheroids without making any clear distinction among them. Generally, if a size-enlargement process produces agglomerates of a size distribution within the range of 0.1 mm to 2.0 mm and a high porosity ( about 20-50%),the process may be called “granulates”. “pelletization” is often referred to as a size-enlargement process that involves the manufacture of agglomerates with a relatively narrow size range ,usually with mean size from 0.25 to 2.0 mm, named “pellets”. Pellets have free-flowing properties and a low porosity ( about 10%).