Abstract

Mustafa Bilge Erdoğan, Necla Benlier, Fevzi Sarper Türker* and Orhan Tarhan

ABSTRACT

Aim: We aimed to investigate relation between high mobility group box-1 protein (HMGB1) levels in peripheral blood and deep vein thrombosis (DVT). Materials and Methods: For this study, HMGB1 levels were compared between lower extremity acute-subacute DVT patients and healthy volunteer subjects. Fifty-three patients (18 to 65 years of age) presenting to the cardiovascular surgery clinic of Private Gaziantep Medikal Park Hospital between April 2018 and April 2019 and 47 controls were included in the study. Biochemical analyses were conducted by the hospital laboratory using the ELISA method. The SPSS for Windows, version 25.0 software was used for statistical analyses of the study data. Results: Increased HMGB1 protein levels were found both in the entire patient group and in patients with proximal and distal DVT versus healthy controls. In the patient group, HMGB1 levels did not significantly differ in relation to age, gender and comorbidities. Conclusion: Increased HMGB1 protein levels as detected in patients with acute/subacute deep vein thrombosis compared to the normal population may be due to inflammation caused by the disease itself as well as the effects of HMGB1 on platelet functions to promote thrombus formation.