World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

SYNTHESIS AND ANTI-CANCER ACTIVITY OF NOVEL QUINAZOLINE DERIVATIVES

K. Dhunmati*, Sandhiya V. and Kousalya M.

ABSTRACT

Objective: The objective of the present study was to synthesize and screen the in-vitro anticancer activity of quinazoline derivative on MCF 7 Cell line. Method: Quinazoline derivatives belonging to the N-containing heterocyclic compounds have caused universal concerns due to their wide and distinct biopharmaceutical activities. The synthesized quinazoline derivatives was screened for anticancer activity against MCF 7 cell line study (via) MTT assay at different concentration level. Result: From the investigation of the study nearly 11 compounds were synthesized out of which two compounds such as 4-(2-fluorophenyl)-1,4,5,6 tetrahydro-2-(methyl thio) benzo quinazoline (C1) and 4-(3,4 dimethoxyphenyl)-1,4,5,6-tetrahydro-2-(methylthio) benzo quinazoline (C2) showed anti cancer activity. Conclusion: From the studies the results reveals that the compound quinazoline derivatives has significant anticancer activity against breast cancer cell line.

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