Abstract

Anonde Andrew Chekwube, Okoroiwu I. L., Okolie N. J. C., Udokwu Euphemia Ifeoma and Obeagu Emmanuel Ifeanyi*

ABSTRACT

The present study was designed to evaluate the effects of co-administration of Myristica Fragrans Houtt (nut meg) and vitamin E on platelets, PT and APTT of potassium bromate intoxicated wistar rats. Dried nuts of nut meg were purchased from Ubani market in Umuahia North Local Government Area, Abia State, Nigeria and were identified by a botanist in the Department of Forestry and Environmental Management, Michael Okpara University of Agriculture, Umudike. In week two and three, there was significant decrease in platelet in all the treatment groups compared with control. There was no significant change in platelet after one week. In week one there was no significant difference in platelet of rats exposed to 10, 30 and 50 mg bromate and those treated with corresponding doses of nutmeg and vitamin E alone. However the combination of doses of nutmeg and vitamin E increased platelet count. In week 2 and 3, there was significant difference in platelet of rats exposed to 10, 30, and 50 mg bromate group, and those treated with corresponding doses of nutmeg and vitamin E alone and in combination compared with rats exposed to bromate alone. In week one, two and three, there was significant increase in average PT in all the treatment groups compared with control. Average PT varied significantly from week one to three in all the treatment groups. In week one two and three, there was significant difference in Average PT of rats exposed to 50 mg bromate and those treated with 500 mg nutmeg and 100 mg vitamin E alone and in combination compared with rats exposed to 50g bromated alone. The trend was similar in groups exposed to 10 and 30mg bromate compared with the respective treatment groups. In week one, two and three, there was significant increase in average APTT in all the treatment groups compared with control. Average APTT varied significantly from week one to three in all the treatment groups. In week one two and three, there was significant difference in Average APTT of rats exposed to 50 mg bromate and those treated with 500 mg nutmeg and 100 mg vitamin E alone and in combination compared with rats exposed to 50mg bromate alone. The trend was similar in groups exposed to 10 and 30mg of bromate compared with the respective treatment groups.