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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301

ICV : 78.6



Dr. Madiha Chisti*, Dr. Ramza Naeem Butt and Dr. Maryam Tariq


Objectives: To identify the frequency of bacterial pathogens in acute exacerbation of COPD. Materials & Methods: This cross sectional was conducted at Department of Pulmonology, Lahore General Hospital from August 2018 to February 2019 over the period of 6 months. A total of 162 patients of acute exacerbation of COPD of age 40-70 years and both genders were included. Patients with h/o concomitant bronchial carcinoma, pneumonia, chronic renal failure and chronic congestive failure were excluded. After taking informed written consent, a fresh sample of sputum was collected into a sterile container and was sent for culture and sensitivity. Each sample was examined and interpreted by consultant pathologist and identification of bacterial pathogens was noted. Results: Mean age was 57.10 ± 7.63 years. Out of the 162 patients, 112 (69.14%) were male and 50 (30.86%) were females with male to female ratio of 2.24:1. In this study, I have found the Streptococcus pneumoniae was the predominant organism isolated in 52 (32.10%) patients followed by Klebsiella pneumoniae in 38 (23.46%), Pseudomonas aeruginosa in 29 (17.90%), Moraxella catarrhalis in 23 (14.30%), Methicillin - Resistant Staphylococcus aureus in 19 (11.73%) and H. influenza in 01 (0.62%) patients of acute exacerbation COPD. Conclusion: This study concluded that streptococcus pneumoniae was the predominant organism isolated in patients of acute exacerbation of COPD followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, Moraxella catarrhalis, Methicillin - Resistant Staphylococcus aureus and H. influenza.

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