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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

FORMULATION, CHARACTERIZATION AND INVITRO EVALUATION OF LAMIVUDINE MICROSPHERES FOR SUSTAINE RELEASE

Y. Phalguna*, Swetha Pothula, Ravinder Kumar Sarepalli and G. Mounika

ABSTRACT

In the present work, Microspheres of Lamivudine using Sodium alginate, Chitosan, Eudragit as polymers were formulated to deliver Lamivudine. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Lamivudine microspheres. FT-IR spectra of the Drug and optimised revealed that the drug is compatible. Micrometric studies revealed that the mean particle size of the prepared microspheres and are suitable for microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling. The invitro drug release decreased with increase in the polymer concentration. Analysis of drug release mechanism showed that the drug release from the formulations followed zero order release kinetics. Based on the results of evaluation tests formulation coded F4 was concluded as best. formulation.

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