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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PHENYTOIN SODIUM

Korem Raju*, MD Rehana Begum, B. Prashanth, G. Manirathnam, D. Chandrashekhar, K. Shashidhar Reddy

ABSTRACT

Fast dissolving tablet of phenytoin sodium was design with a view to provide a quick onset of action. The main objective of the study was to formulate fast dissolving tablets of phenytoin to achieve a better dissolution rate and further improving the bioavailability of the drug. Here Fast dissolving tablets were prepared by direct compression by using super disintegrants such as SSG,MCC and sodium alginates etc. Before preparing evaluated pre-compression parameters that results found to be within I.P limits. Among the all the 6 formulations F4 formulation containing SSG,MCC as super disintegrants considered to be best formulation which shows 98.7% drug release.

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