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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

A REVIEW ON ASSOCIATION OF CD14 WITH INCIDENT DEMENTIA AND MARKERS OF BRAIN AGEING AND INJURY

*Jesna Jose, Lincy George and K. Krishnakumar

ABSTRACT

The soluble cluster of differentiation 14 is a type of CD14 which is a glycoprotein expressed on monocytes and neutrophils. CD14 is involved in the innate immunity and facilitate pro-inflammatory and anti-inflammatory cytokines. Current researchers found that CD14 is a key component of incident dementia and also involved as a marker of brain aging and injury. Usually, the dementia forms such as Alzheimer’s are diagnosed in later stages after sufficient damage to the brain had occurred. So, a marker like CD14can plays a vital role by the light of current researches that it could help in early detection and less costly. With this key component the detection of damage and injury can be including cognitive decline can be identified.

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