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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

EVALUATION OF MEAN MALARIA PARASITAEMIA BEFORE AND AFTER TREATMENT IN MICE

Esimai Bessie Nonyelum*, Obeagu Emmanuel Ifeanyi and Njoku O. O.

ABSTRACT

Holistic management of malaria with Antioxidant Vitamins A.C.E'. In animal model was employed. Gnotobiotcally reared male Swiss albino mice were inoculated with a standard dose of p. berghei, about 107 parasitized erythrocytes through intrapertional route. Treatment was administered according to body weight of mouse through intrperitoneal route, observing the lethal dose of Vitamins through the route. The blood was evaluated parasitologically. There was a highly significant decrease (p<0.0001) in parasitaemia, consequent to total clearance in all mice treated with antioxidant vitamin. A hundred (100 percent) mortality was recorded in positive untreated control group. Post mortem examinations revealed haemorrhagic lesions at the lower part of the brain. There was an effective treatment by orthomolecular approach.

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