EVALUATION OF MEAN MALARIA PARASITAEMIA BEFORE AND AFTER TREATMENT IN MICE
Esimai Bessie Nonyelum*, Obeagu Emmanuel Ifeanyi and Njoku O. O.
Holistic management of malaria with Antioxidant Vitamins A.C.E'. In animal model was employed. Gnotobiotcally reared male Swiss albino mice were inoculated with a standard dose of p. berghei, about 107 parasitized erythrocytes through intrapertional route. Treatment was administered according to body weight of mouse through intrperitoneal route, observing the lethal dose of Vitamins through the route. The blood was evaluated parasitologically. There was a highly significant decrease (p<0.0001) in parasitaemia, consequent to total clearance in all mice treated with antioxidant vitamin. A hundred (100 percent) mortality was recorded in positive untreated control group. Post mortem examinations revealed haemorrhagic lesions at the lower part of the brain. There was an effective treatment by orthomolecular approach.[Full Text Article]