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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

BIOLOGICALLY ACTIVE COMPOUNDS BASED ON OROTIC ACID

*Ubaydulla Baltabaev, Abdukakhkhor Juraev, Abdugafur Khajimetov, Jahongir Abduvakilov, Nusrat Akhmadaliev and Feruzbek Ubaydullaev

ABSTRACT

In this paper, it was of interest to synthesize derivatives of 1,3-bis (aroylthiocarbamoyl) -orotic acid in order to increase the arsenal of biologically active compounds. By the interaction of chloro-, bromo-, iodo- and nitro-substituted benzoyl-isothiocyanates with orotic acid in the environment of pyridine and dimethylformamide, at a temperature of 100-1050? and a reaction time of 5 hours, derivatives of 1,3-bis (aroylthiocarbamoyl) -orotic acid were synthesized. Among the synthesized compounds, effective anti-inflammatory drugs were identified, as well as substances with bactericidal and fungicidal properties, which are of undoubted practical interest.

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